Clinical trial shows that the use of Vitamin D supplement improves sleep quality

Randomized Controlled Trial

Mohammad Shahi Majid et al. Nutr Neurosci. 2018 Sep.

doi: 10.1080/1028415X.2017.1317395. Epub 2017 May 5.

Authors

Mohammad Shahi Majid  ¹ , Hosseini Seyed Ahmad  ¹ , Helli Bizhan  ¹ , Haghighi Zade Mohammad Hosein  ² , Abolfathi Mohammad  ³

Affiliations

• ¹ a Departments of Nutritional Science, Paramedical Faculty , Ahvaz Jundishapur Medical Sciences University , Ahvaz , Iran.
• ² b Department Biostatistics , School of Health, Ahvaz Jundishapur University of Medical Science , Ahvaz , Iran.
• ³ c Department of Nutritional Science , Arvand International Division of Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

• PMID: 28475473
• DOI: 10.1080/1028415X.2017.1317395

Abstract

Objectives: Sleep quality may be directly related with vitamin D serum level. Some studies found that people with lower vitamin D serum level experienced a lower sleep quality. Consequently, this study aimed at determining the effect of vitamin D supplements on sleep score and quality in 20-50 year-old people with sleep disorders.

Methods: This double blind, clinical trial was performed in November 2015-February 2016 on 89 people with sleep disorders based on Petersburg's Sleep Index. Patient samples were divided randomly into two groups: intervention and placebo. At the end of the study, the data on 89 subjects (44 in intervention group and 45 people in placebo group) were examined. Intervention group received a 50 000-unit vitamin D supplement, one in a fortnight for 8 weeks. Meanwhile, placebo group received placebo. Before and after intervention, Petersburg's Sleep Quality Questionnaire, International Physical Activity Questionnaire, general information questionnaire, sun exposure, vitamin D serum level and 3-day food record questionnaire were assessed and recorded for all participants. To analyze data, t-test, chi square, ANCOVA, U-Mann-Whitney and Wilcoxon statistical tests were used.

Findings: Based on the results of the present study, at the end of the study sleep score (PSQI) reduced significantly in vitamin recipients as compared with placebo recipients (P < 0.05). This difference was significant even after modifying confounding variables (P < 0.05).

Conclusion: This study shows that the use of vitamin D supplement improves sleep quality, reduces sleep latency, raises sleep duration and improves subjective sleep quality in people of 20-50 year-old with sleep disorder.

Keywords: Serum vitamin D; Sleep disorders; Vitamin D supplement.

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