Daily Step Count and All-Cause Mortality: A Dose-Response Meta-analysis

Ahmad Jayedi et al. Sports Med. 2022 Jan.

doi: 10.1007/s40279-021-01536-4. Epub 2021 Aug 21.

Authors

Ahmad Jayedi  ^{1   2} , Ali Gohari  ³ , Sakineh Shab-Bidar  ⁴

Affiliations

• ¹ Food Safety Research Center (Salt), Semnan University of Medical Sciences, Semnan, Iran.
• ² Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P. O. Box 14155/6117, Tehran, Iran.
• ³ Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran.
• ⁴ Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P. O. Box 14155/6117, Tehran, Iran. s_shabbidar@tums.ac.ir.

• PMID: 34417979
• DOI: 10.1007/s40279-021-01536-4

Abstract

Background: Uncertainty remains about the optimum step count per day for health promotion.

Objective: We aimed to investigate the association between step count per day and all-cause mortality risk.

Methods: PubMed, Scopus, and ISI Web of Science were searched to January 2021 to find prospective cohort studies of the association between device-based step count per day and all-cause mortality risk in the general population. Two reviewers extracted data in duplicate and rated the certainty of evidence using the GRADE approach. Study-specific hazard ratios (HRs) were pooled using a random-effects model.

Results: Seven prospective cohort studies with 175,370 person-years and 2310 cases of all-cause mortality were included. The HR for each 1000 steps per day was 0.88 (95% CI 0.83-0.93; I² = 79%, n = 7) in the overall analysis, 0.87 (95% CI 0.78-0.97; I² = 59%, n = 3) in adults older than 70 years, and 0.92 (95% CI 0.89-0.95; I² = 37%, n = 2) in studies controlled for step intensity. Dose-response meta-analysis indicated a strong inverse association, wherein the risk decreased linearly from 2700 to17,000 steps per day. The HR for 10,000 steps per day was 0.44 (95% CI 0.31-0.63). The certainty of evidence was rated strong due to upgrades for large effect size and dose-response gradient.

Conclusions: Even a modest increase in steps per day may be associated with a lower risk of death. These results can be used to develop simple, efficient and easy-to-understand public health messages.

Similar articles

• Suicidal Ideation.

  Harmer B, Lee S, Duong TVH, Saadabadi A. Harmer B, et al. 2021 Aug 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. 2021 Aug 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 33351435 Free Books & Documents. Review.
• Association of Daily Step Count and Step Intensity With Mortality Among US Adults.

  Saint-Maurice PF, Troiano RP, Bassett DR Jr, Graubard BI, Carlson SA, Shiroma EJ, Fulton JE, Matthews CE. Saint-Maurice PF, et al. JAMA. 2020 Mar 24;323(12):1151-1160. doi: 10.1001/jama.2020.1382. JAMA. 2020. PMID: 32207799 Free PMC article.
• Aspirin Use in Adults: Cancer, All-Cause Mortality, and Harms: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet].

  Whitlock EP, Williams SB, Burda BU, Feightner A, Beil T. Whitlock EP, et al. Rockville (MD): Agency for Healthcare Research and Quality (US); 2015 Sep. Report No.: 13-05193-EF-1. Rockville (MD): Agency for Healthcare Research and Quality (US); 2015 Sep. Report No.: 13-05193-EF-1. PMID: 26491756 Free Books & Documents. Review.
• The relationships between step count and all-cause mortality and cardiovascular events: A dose-response meta-analysis.

  Sheng M, Yang J, Bao M, Chen T, Cai R, Zhang N, Chen H, Liu M, Wu X, Zhang B, Liu Y, Chao J. Sheng M, et al. J Sport Health Sci. 2021 Dec;10(6):620-628. doi: 10.1016/j.jshs.2021.09.004. Epub 2021 Sep 20. J Sport Health Sci. 2021. PMID: 34547483 Free PMC article. Review.
• Daily step count and incident diabetes in community-dwelling 70-year-olds: a prospective cohort study.

  Ballin M, Nordström P, Niklasson J, Alamäki A, Condell J, Tedesco S, Nordström A. Ballin M, et al. BMC Public Health. 2020 Nov 30;20(1):1830. doi: 10.1186/s12889-020-09929-2. BMC Public Health. 2020. PMID: 33256704 Free PMC article.

See all similar articles

References

1. 1. World Health Organization. Global recommendations on physical activity for health: World Health Organization; 2010.
2. 1. Ekelund U, Tarp J, Fagerland MW, Johannessen JS, Hansen BH, Jefferis BJ, et al. Joint associations of accelero-meter measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals. Br J Sports Med. 2020;54(24):1499–506. - PubMed
3. 1. Ekelund U, Tarp J, Steene-Johannessen J, Hansen BH, Jefferis B, Fagerland MW, et al. Dose–response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. BMJ. 2019;366:l4570. - PubMed - PMC
4. 1. Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS, et al. Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis. Ann Intern Med. 2015;162(2):123–32. - PubMed
5. 1. Patterson R, McNamara E, Tainio M, de Sá TH, Smith AD, Sharp SJ, et al. Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis. Berlin: Springer; 2018.

Publication types

LinkOut - more resources

• Full Text Sources

  • Springer

from Hacker News https://ift.tt/3qLBuqa